CREST-E builds on previous trials of creatine to prove creatine slows progression in Huntington’s disease.
CREST-E was the largest ever trial of creatine, with 551 volunteers for 3 years each; it also employed the highest dose of creatine - up to 40 grams per day.
Huntington’s disease researchers and drug-hunters across the globe have been hard at work studying the effects of the HD mutation and coming up with treatments designed with HD specifically in mind. This is in contrast to substances like creatine, which were thought to be beneficial for the brain in a much more general way.
Full report here ... Largest creatine clinical trial for Huntington's disease halted after 'futility' analysis
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